Abstract: In the design of a centrifuger nacelle, a topology optimization was carried out with respect to the requirements of the mass and stiffness. The design area, loads and boundary conditions were determined based on the centrifuger nacelle’s external size, connecting boundary, loaded mass and the max acceleration. The finite element model was constructed using the Ansys software. The objective was to make the stiffness of the nacelle maximal, with the mass as the constraint in the topology optimization. The model was solved by the Tosca software. The structure after the topology optimization enjoys good stiffness under the requirement of the mass.