Abstract: This paper discusses multi-A/D data coding, reading from and writing into large capacity flash memory in finite hardware resource, USB interface design of half-reclaimable data acquisition and storage system based on FPGA. The system was modularly designed with VHDL and QuartusⅡ7.1 software. The test results show that the system can perform data acquisition and storage of 16 channels with 16 kHz sampling frequency, with speed of 8 Mbit/s with communication to computer, and with a proven system reliability.