Abstract: In the vacuum thermal tests for spacecraft, various kinds of programmable instrument are used, with different communication interfaces, bus types and driving modes, and it is often difficult to develop the application software for measurement and control with universality and inheritance. This paper develops universal instrument driver functions based on VISA, which are encapsulated with the dynamic link library technology to be easily called by users in secondary developments. These functions could simplify the configuration of the instrument driving process and the general design of the measurement and control software.