Abstract: An optimized model of a structure under vibrafuge environment is built with the fix angle as the design variable. At the same time, the rationality of the fix position is used as the restrictive condition and the RMS value of the acceleration at key points is used as the objective function. The parameter design language (APDL) of ANSYS is applied to perform the sensitivity analysis and the optimization of the structural vibration response under the centrifuge field. The vibration response is obtained after the optimization.