Abstract: During vehicle launch and descent, rapid changes in ambient and cabin pressure can creat differential pressure loads that may lead to structural failure and inadequate adaptation of cabin equipment to low-pressure environment. This study proposed a method for analyzing the dynamic characteristics of cabin pressure based on one-dimensional isentropic flow analysis. The effects of various factors, including the tilt angle of the surface where ventilation hole located, venting area, cabin air volume, and vehicle acceleration, on cabin pressures were investigated. The results show that cabin pressure increases with the tilt angle of the surface where ventilation hole located during ascent but reaches equilibrium quickly upon entering the cruise stage. The differential pressure between the cabin interior and exterior increases with the ratio of cabin air volume to venting area. Additionally, as ascent acceleration increases, cabin pressure decreases more rapidly, leading to a highter differential pressure. This research provides a reference for the design of aircraft ventilation holes and the development of equipment suitable for low-pressure conditions.