Abstract: In order to study the effect of structural parameters of the stainless steel plate heat sink on its flow and heat transfer performance to improve the heat exchange efficiency, the software ANSYS was used to establish a geometric model of the heat sink that was consistent with the real structure but with different flow path height, solder joint diameter and solder joint arrangement. The software Fluent was used to conduct the numerical simulation. The results show that, under the equal flow velocity, larger flow path height H and smaller solder joint diameter D would reduce the flow resistance of the heat sink and improve the temperature uniformity, thereby improving the heat transfer of the heat sink. When the liquid supply pressure is sufficient, for the heat sinks whose solder joint arrangements are rectangular and rhombic, although the latter’s flow resistance is relatively larger, it had higher temperature uniformity. The research may provide a reference for the structural design and optimization of the stainless steel plate heat sink.