Abstract: In order to study the comprehensive impact of different structural parameters on the heat transfer and resistance performance of honeycomb plate under large heat flow, a numerical modeling of honeycomb plate was constructed under the frame of target-driven optimization system based on the ANSYS Workbench platform. And a central composite design optimization algorithm was used to analyze the flow field and to implement multi-objective optimization. The results show that the flow and heat transfer of fluid in honeycomb plate exhibits periodic changes. The fluid is strongly disturbed and generated jets and small eddies when flowing through the solder joints, which could effectively strengthen the heat transfer. It can be concluded that the bulge height H has the greatest impact on heat transfer and resistance performance; the next important factor is the solder joint diameter D, while the solder joint spacing L has the smallest impact. Through optimization calculation, three groups of superior structural parameters are obtained, which may provide a reference for the optimal design of honeycomb plate.