Abstract: To develop an integrated motion simulation system for aerospace medical research, based on the rotating arm structure of a centrifuge, the frame type self-rotating seat was used to replace the traditional fixed seat, and a chain drive was introduced as the rotation drive. The centrifuge control system with PC, programmable logic controller (PLC), servo motor and encoder, as well as the self-rotating seat control system with IPC, driver and stepper motor was built. In terms of control system software design, attention was paid to the real-time operation monitoring of centrifuge and the stability control of portable self-rotating seat. The precision tests of three simulated environments of hypergravity, rotation and hypergravity rotation composite were carried out to the developed platform. The results show that the platform can achieve simulations of hypergravity, rotation and hypergravity rotation composite. Both the centrifuge and self-rotating seat have high control precision, and the operation process is safe and stable, meeting the expected requirements. The platform can be used for experimental research of biological physiological response or equipment testing in aerospace special environment.