Abstract: In order to ensure the imaging quality of the multi-load remote-sensing satellite for high-precision splicing with the expanded image width, the spatial layout of the multiple loads is optimized with consideration of the coupling between the multiple loads, and a thermo-structural integration design scheme is proposed. The improved Heaviside density filter topology optimization method is applied to obtain the optimal structure/thermal material distributions, the multi-objective genetic algorithm is used for the detailed optimization design, and the Pareto front solution groups of the mass of the support structure are used to obtain the first-order natural frequency and the RMS of the surface figure. The optimized parameters of the support structure are obtained: the first-order natural frequency is 384.8 Hz; the mass is 9.47 kg; the configuration accuracy of the installation face is 0.004 0 mm. Then, the static load and the thermal deformation analyses are carried out, together with the vibration and structural test validation. It is shown that the support structure enjoys a good balance between light weight and structural & thermal stability in that the pointing accuracy of the star sensor is better than 9″, and the angle change between the optical axes of dual cameras is acceptable. Therefore, the support structure can meet the requirements of the remote sensing satellite for high-quality imaging.