Abstract: In view of the harsh conditions of the vibration test of the complex integrated circuits used in aerospace and the complex characteristics of the chip packaging, this paper presents the optimization design of the vibration fixture, with a complex integrated circuit packaged with the CQFP228 for the aerospace usage as an example, using the ANSYS Workbench software based on the topology optimization and the multi-objective genetic algorithm (MOGA). The sweep frequency vibration and the random vibration response of the fixture structure are simulated and analyzed. Finally, the applicability and the rationality of the design are verified by experiments, which is shown to be able to solve the problems of the test resonance, the poor dynamic response and the excessive fixture weight.