Abstract: In view of the strong coupling between some special autonomous temperature control strategies of the thermal control and the mission background, the space environment and the controlled object parameters, it is difficult to verify their correctness and rationality in advance by the traditional ground comprehensive test methods. Combined with the temperature requirements of Chang’e-5 lunar exploration mission propulsion tank and the design process of its special independent temperature control strategy, a reasoning evaluation method based on the comprehensive testing and the expert knowledge of thermal control designers is proposed. The optimized test cases are used to verify the method. The results show that the first version of the temperature control strategy can achieve the expected goal of reducing the temperature difference between tanks, but it is not suitable for the specific task background, Finally, some suggestions are made to optimize and improve the control strategy, so as to realize and optimize the closed-loop development mode of the “initial design → the test verification → the improvement”, which has an important popularization and application value in engineering.