Abstract: In order to protect the space flexible inflatable sealed cabin from the space debris impact in orbit, a multi-layer flexible protective structure filled with layers of Basalt fiber cloth and Kevlar fiber cloth is proposed. The impact limit of the Nextel/Kevlar fiber cloth filled protective structures with different structural parameters is simulated and analyzed based on the Christiansen impact limit equation, including the influencing factors of the total spacing of the protective layers, as well as the number of the layers of the Nextel fiber cloth and the Kevlar fiber cloth. The results provide a basis for the optimal design of the strength-weight ratio of the protective structure. The hypervelocity impact test of the Basalt/Kevlar fiber cloth filled protective structure is carried out by using a two-stage light gas gun. The impact limit data of the protective structure in different speed zones are obtained, and the experimental results are compared with the impact limit simulation analysis curve. It is confirmed that the Basalt/Kevlar fiber cloth filled protective structure has adequate capability of debris protection for the space flexible inflatable sealed cabin.