Abstract: The isolation of the vibrations of satellite and rocket systems is important to improve the vibration environment of the satellite in the launch stage. In order to suppress the vibration of the satellites, the vibration isolation platforms with a serial magnetorheological damper and with a parallel viscous damper are designed, respectively. Based on the middle-sized satellite specimen, a test system is built for validating the whole-spacecraft’s vibration isolation effect. It is shown that with the magnetorheological damper, a fairly satisfactory reduction of the vibration is realized with a certain mass control but at a price of the natural frequency of the system being changed; while the parallel viscous damper performs fairly well in x direction, yet brings about no significant difference in y and z directions. The result provides a basis for the practical engineering application of the whole-spacecraft vibration isolation.