Abstract: The compatibility between the work fluid and the bearing material in the fluid loop of the spacecraft is studied experimentally in this paper. The compatibility experiment between several materials and N(C₂F₅)₃ is carried out. The appearance, the acid value, the volume fraction of the distillate, the kinematic viscosity, and the essential components of N(C₂F₅)₃ are characterized before and after the experiment. Meanwhile, the concerned properties are the mass, the corrosion rate, the surface topography of the metallic material, as well as the mass, the mechanical properties of the non-metallic materials. From the integrated analysis of the test results, it is shown that the compatibility is acceptable to the highest level between N(C₂F₅)₃ and the aluminum alloys 5A06, 7A04, 1035, the stainless steel 316L, the titanium alloy TC11, the composites PI/MoS₂/F₄, and Si₃N₄. The study can provide some reference for the compatibility design of fluid loop for spacecraft applications.