Abstract: The geo-neutrinos detection is a practical way to study the structure and the composition of the interior Earth. The volume of the liquid scintillation detector is usually too small to distinguish the model of the mantles, while the volume of the liquid scintillation detector of Jiangmen Underground Neutrino Observatory (JUNO) can reach as high as 20 000 tons. Thus the geo-neutrinos signals from the JUNO are analyzed to obtain an estimation of (34.50±4.78)TNU with the LITHO1.0 model. It is shown that the influence of the radioactive element abundance uncertainty in the crust on the global crustal neutrino signal is significantly greater than that of the uncertainty of the crustal density and the crustal thickness.