Abstract: With the increasing demand for the power of the spacecraft load, the reliability of the motor driver circuit becomes a more and more important issue in the product design. Using the integrated component in the motor driver circuit is considered as a mature method. In this paper, a method for the single event latch-up protection by using high speed and reparable motor driver circuit based on the MSK4351 is proposed, and the simulation test verifies that the protection circuit can make automatic detection of the latch-up and rapid release from the state of latch-up. The product's risk of single event effect is analyzed based on its working state in the outer space, and the result indicates that the risk is acceptable and this motor driver circuit works well until now, which further proves that the method proposed in this paper has a value for the future engineering application.