Abstract: The interior noise of a space station module is simulated, with acoustic parameter settings. Two typical vibro-acoustic analysis methods, namely the coupled FE/FEM and SEA, are adopted to simulate and analyze the space station module under inner acoustic source excitation. The interior noise validation test of the space station is designed. A sound source simulation technology based on the acoustic power equivalence is proposed. The compared results show that the acoustic levels in both low and high frequency regions can be predicted by using both methods, and the overall level of deviation is less than 2 dB. The layout of the sound source is optimized through analyses, and it is shown that the centralized layout is more conducive for the noise reduction.