Abstract: The combination of the V-pattern folded cores and the forced convection may apply to the multifunctional design the simultaneous load bearing and the heat dissipation for hypersonic vehicles or high-power electronic devices. The heat transfer and thermal stress characteristics of a V-pattern folded core sandwich panel subjected to the forced convection are investigated numerically to obtain the velocity field, the temperature field, and the structural thermal stress distribution. It is shown that the heat transfer performance of the V-pattern folded panels is evidently improved under the forced convection, however, an elevated pressure drop is also observed. The coolant velocity varies periodically with the geometrical construction and reaches the maximum value close to the peak position of the buckling, where the heat convection is therefore reinforced. The temperature increases along the flow direction and sees a periodic fluctuation. The overall heat transfer performance is refined with the increase of the inlet velocity. The thermal stress as well as the deformation are comparatively large in the face sheet near the heat source and the stress concentration is found at the folding positions.