Abstract: For the purpose of space science experiment of various materials, a device is designed to serve for the comprehensive materials science experiment, which can work in space for a long time. The design process of the sample lifting mechanism, the sample fixture structure and the ergonomics are presented in detail. Experimental results show the feasibility and the practicality of the design theory and method. The device works smoothly and reliably in the experiment, and the experimental samples are found to be intact and not damaged. The device realizes the management and replacement functions of the multi-batch samples, and the manual operation function on orbit for the first time.