Abstract: In view of the fact that the mission requirement analysis of the existing human-machine interface for the manned spacecraft does not cover every aspect and the system design is not sufficient, an integrated design method of human-machine interface for the manned spacecraft based on systems engineering is proposed. The reasonability and the validity of the method are shown through an example of the human-machine interface design. The application results show that with this method, the design efficiency is significantly improved, the repetition in the design process is reduced, and the human-machine interface design is made more reasonable.