Abstract: The noise inside a manned spacecraft pressurized cabin in orbit is an important issue for astronauts. In this paper, a non-linear regression analysis method for the noise in the manned spacecraft pressurized cabin is proposed. From the noise data of a manned spacecraft pressurized cabin, the on-orbit position-noise math model is built by this method. It is shown that the noise deviation between the value calculated by the on-orbit math model and the value measured by test is less than 4%. The model could offer predicted on-orbit noise data for the noise reduction design, the noise simulation and the noise reduction measure verification on the ground stage.