Abstract: The change of the electron density in the ionosphere due to the natural or artificial disturbances would influence the propagation of the electronic waves. In this paper, the ionospheric perturbation by the artificial SF₆ gas release is simulated. In terms of the diffusion process of the SF₆ gas and the relevant ion-chemistry reactions in the ionosphere together with experimental measurements, the density of the ionospheric electron varied with the mass flux of the SF₆ gas released is determined. The results show that the depletion of the ionospheric electron density is remarkable after the release of the SF₆ gas, and the electron density decreases exponentially with the SF₆ gas flux released to some extent. The results can provide some guidance for future theoretical studies for enhancing satellite communication safety and implementing communication interference.