Abstract: For a strongly coupled temperature and humidity control system for a manned spacecraft sealed-cabin(mssc-THCS), a temperature-humidity independent control method(THICM) based on the absolute humidity control is proposed. The THICM contains two independent thermal control liquid loops: the moderate temperature loop (MTL) and the low temperature loop(LTL), and through the independent regulation of the MTL thermal control valve(MTL-TCV) and the LTL thermal control valve(LTL-TCV), a dual goal decoupling control of the humidity control based on the CHX(condensing heat exchanger) and the temperature control based on the gl-HX(gas-liquid heat exchanger) is implemented to meet the strict requirement of the mssc-THCS. Typical system configurations and the control strategy of the temperature-humidity independent control system for a manned spacecraft sealed-cabin(mssc-THICS) are presented, and the ground-based experiment validation system is built to carry out the validation experiment related with the temperature-humidity independent control. The experiment results show that good control effects of the temperature within ±0.5℃ and the relative humidity within ±2% are achieved, which lays a good foundation for the engineering application in the mssc-THICS.